Alpha-2-macroglobulin (A2M) is a plasma protein and is found in significant quantities in the blood. A2M has been described as a broad spectrum multi-purpose protease inhibitor. This means that it is able to inactivate a variety of proteinases that are known to degrade cartilage. 1–2 Osteoarthritis (OA) is in part due to the diseased joint overproducing several chemicals that slowly erode cartilage.

By inhibiting these chemicals (proteases), alpha-2- macroglobulin can stop the progression of OA by preventing the cartilage from breaking down and avoiding cartilage loss, which improves joint function and decreases pain.

A2M Therapy OA is a common health problem that can cause knee pain. Temporary relief from the pain caused by OA can generally be achieved with non-surgical treatment options such as NSAIDs, cortisone and viscosupplementation (HA), but relief is only temporary while the root causes of osteoarthritis remain.

For long term relief of OA symptoms, a highly concentrated injection of alpha-2-macroglobulin can impact the progression of the disease. Alpha-2-macroglobulin binds to the chemicals produced in the joints that degrade cartilage and neutralizes their degenerative effect in a dose dependent manner.